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Administration of Continual pain continues to stand for a region of wonderful unmet biomedical need. Despite the fact that opioid analgesics are usually embraced given that the mainstay of pharmaceutical interventions With this location, they suffer from sizeable liabilities that include addiction and tolerance, in addition to melancholy of respira

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Regardless of the questionable efficiency of opioids in controlling CNCP as well as their substantial charges of Negative effects, the absence of obtainable different medications as well as their scientific limitations and slower onset of action has triggered an overreliance on opioids. Conolidine is undoubtedly an indole alkaloid derived from the

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